Diagnosis of disseminated candidiasis by measurement of urine D-arabinitol/L-arabinitol ratio

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Urine D-arabinitol/L-arabinitol ratio in diagnosis of invasive candidiasis in newborn infants.

Infants treated in neonatal intensive care units suffer an increased risk for invasive candidiasis, but the diagnosis is sometimes difficult. D-arabinitol is a metabolite of most pathogenic Candida species. An elevated urine D-arabinitol/L-arabinitol (DA/LA) ratio is a sensitive sign of invasive candidiasis in children with cancer, but the method has not been previously evaluated for newborn in...

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1-De­oxy-d-arabinitol

Addition of methyl lithium to d-erythrono-1,4-lactone followed by acid deprotection was shown, by X-ray crystallography, to give 1-de-oxy-d-arabinitol, C(5)H(12)O(4), rather than 1-de-oxy-d-ribitol as the major product. The crystal structure exists as hydrogen-bonded chains of mol-ecules running parallel to the c axis which are further linked together by hydrogen bonds. Each mol-ecule is a dono...

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ژورنال

عنوان ژورنال: Journal of Clinical Microbiology

سال: 1996

ISSN: 0095-1137,1098-660X

DOI: 10.1128/jcm.34.9.2175-2179.1996